Numerous population-based studies and observational studies have shown one to oophorectomy is associated which have a greater danger of colorectal malignant tumors (CRC), and you may hormones substitute for procedures has been for the a decrease in the risk of colorectal cancer. This study try accomplished to analyze if or not hysterectomy, which could affect the quantities of female hormones, are associated with a risk of cancers of your own particular gastrointestinal tract.
Measures
That it population-built retrospective cohort data try conducted playing with insurance coverage analysis provided with medical Insurance Remark and you can Investigations Service (HIRA) away from . This new hysterectomy category integrated 40- so you’re able to 59-year-old women who underwent hysterectomy with uterine leiomyoma or uterine endometriosis off . The latest control category provided women old 40 so you’re able to 59 decades which decided to go to medical organizations to own scientific test off .
Abilities
The fresh hysterectomy and you may non-hysterectomhy organizations composed 66,204 and you may 89,768 victims, respectively. The fresh new median decades from the low-hysterectomy group and hysterectomy classification was in fact forty eight (range: 43–53) and you will 46 (range: 44–49) age, respectively. From the unadjusted results of the analysis, all colorectal disease (CRC) enhanced in the hysterectomy alone group (Hours step one.222, 95% rely on interval (CI) step one.0step one6–step 1.47, p = 0.033), sigmoid colon cancer improved regarding hysterectomy by yourself classification (Hr step 1.71, 95% CI step one.073–dos.724, p = 0.024), and rectal cancer tumors improved throughout the hysterectomy having adnexal surgery group (Time step one.924, 95% CI step 1.073–2.724, p = 0.002). “The elevated likelihood of colorectal malignant tumors about women who undergone hysterectomy in the South Korean Federal Health insurance Database”の続きを読む